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Influenza vaccine effectiveness in preventing hospitalizations with laboratory-confirmed influenza in Greece during the 2014-2015 season: A test-negative study.
J Med Virol. 2016 11; 88(11):1896-904.JM

Abstract

The 2014-2015 influenza season was marked by circulation of antigenically drifted A/H3N2 strains, raising the possibility of low seasonal influenza Vaccine Effectiveness (VE). We assessed VE against hospitalization with laboratory-confirmed influenza for the 2014-2015 season, using routine surveillance data. Non-sentinel swab samples from Greek hospital inpatients were tested for influenza by RT-PCR in three laboratories, covering the entire country. We estimated VE using a test-negative design. Out of 883 patients with known vaccination status, 161 (18.2%) were vaccinated, and 392/883 patients (44.4%) tested positive for influenza, of whom 162 (41.3%) had type B and 151 (38.5%) had A/H3N2. Adjusted VE was 31.6% (95%CI: 2.9-51.8%) against any influenza, 46.8%, 95%CI: 12.5-67.6%) against type B and -1.9%, 95%CI: -69.5 to 38.7%) against A/H3N2. VE against non-ICU hospitalization appeared to be higher, but the difference did not reach statistical significance. Circulating A/H3N2 viruses showed substantial antigenic drift, while about half of the type B strains were similar to the vaccine strain. Despite the antigenic drift of the A/H3N2 strains, the vaccine still offered substantial protection against hospitalization with laboratory-confirmed influenza, mostly due to a surge in type B influenza late in the season. Vaccine coverage was low, even among groups targeted for vaccination, and considerable effort should be made to improve it. J. Med. Virol. 88:1896-1904, 2016. © 2016 Wiley Periodicals, Inc.

Authors+Show Affiliations

Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.National Influenza Reference Laboratory for Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece.National Influenza Reference Laboratory for Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.National Influenza Reference Laboratory for Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.Antimicrobial Resistance and Health Associated Infections Laboratory, Central Public Health Laboratory, Hellenic Centre for Disease Control and Prevention, Athens, Greece. European Public Health Microbiology Training programme (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece.National Influenza Reference Laboratory for Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27088266

Citation

Lytras, Theodore, et al. "Influenza Vaccine Effectiveness in Preventing Hospitalizations With Laboratory-confirmed Influenza in Greece During the 2014-2015 Season: a Test-negative Study." Journal of Medical Virology, vol. 88, no. 11, 2016, pp. 1896-904.
Lytras T, Kossyvakis A, Melidou A, et al. Influenza vaccine effectiveness in preventing hospitalizations with laboratory-confirmed influenza in Greece during the 2014-2015 season: A test-negative study. J Med Virol. 2016;88(11):1896-904.
Lytras, T., Kossyvakis, A., Melidou, A., Andreopoulou, A., Exindari, M., Gioula, G., Kalliaropoulos, A., Tryfinopoulou, K., Pogka, V., Spala, G., Malisiovas, N., & Mentis, A. (2016). Influenza vaccine effectiveness in preventing hospitalizations with laboratory-confirmed influenza in Greece during the 2014-2015 season: A test-negative study. Journal of Medical Virology, 88(11), 1896-904. https://doi.org/10.1002/jmv.24551
Lytras T, et al. Influenza Vaccine Effectiveness in Preventing Hospitalizations With Laboratory-confirmed Influenza in Greece During the 2014-2015 Season: a Test-negative Study. J Med Virol. 2016;88(11):1896-904. PubMed PMID: 27088266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccine effectiveness in preventing hospitalizations with laboratory-confirmed influenza in Greece during the 2014-2015 season: A test-negative study. AU - Lytras,Theodore, AU - Kossyvakis,Athanasios, AU - Melidou,Angeliki, AU - Andreopoulou,Anastasia, AU - Exindari,Maria, AU - Gioula,Georgia, AU - Kalliaropoulos,Antonios, AU - Tryfinopoulou,Kyriaki, AU - Pogka,Vasiliki, AU - Spala,Georgia, AU - Malisiovas,Nikolaos, AU - Mentis,Andreas, Y1 - 2016/04/26/ PY - 2016/04/14/accepted PY - 2016/4/19/entrez PY - 2016/4/19/pubmed PY - 2017/8/2/medline KW - epidemiology KW - immunity/immunization KW - influenza virus KW - seasonal incidence KW - surveillance KW - vaccine effectiveness KW - vaccines/vaccine strains SP - 1896 EP - 904 JF - Journal of medical virology JO - J Med Virol VL - 88 IS - 11 N2 - The 2014-2015 influenza season was marked by circulation of antigenically drifted A/H3N2 strains, raising the possibility of low seasonal influenza Vaccine Effectiveness (VE). We assessed VE against hospitalization with laboratory-confirmed influenza for the 2014-2015 season, using routine surveillance data. Non-sentinel swab samples from Greek hospital inpatients were tested for influenza by RT-PCR in three laboratories, covering the entire country. We estimated VE using a test-negative design. Out of 883 patients with known vaccination status, 161 (18.2%) were vaccinated, and 392/883 patients (44.4%) tested positive for influenza, of whom 162 (41.3%) had type B and 151 (38.5%) had A/H3N2. Adjusted VE was 31.6% (95%CI: 2.9-51.8%) against any influenza, 46.8%, 95%CI: 12.5-67.6%) against type B and -1.9%, 95%CI: -69.5 to 38.7%) against A/H3N2. VE against non-ICU hospitalization appeared to be higher, but the difference did not reach statistical significance. Circulating A/H3N2 viruses showed substantial antigenic drift, while about half of the type B strains were similar to the vaccine strain. Despite the antigenic drift of the A/H3N2 strains, the vaccine still offered substantial protection against hospitalization with laboratory-confirmed influenza, mostly due to a surge in type B influenza late in the season. Vaccine coverage was low, even among groups targeted for vaccination, and considerable effort should be made to improve it. J. Med. Virol. 88:1896-1904, 2016. © 2016 Wiley Periodicals, Inc. SN - 1096-9071 UR - https://news.unboundmedicine.com/medline/citation/27088266/Influenza_vaccine_effectiveness_in_preventing_hospitalizations_with_laboratory_confirmed_influenza_in_Greece_during_the_2014_2015_season:_A_test_negative_study_ L2 - https://doi.org/10.1002/jmv.24551 DB - PRIME DP - Unbound Medicine ER -