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[Colchicine: old medication with new benefits : Use in rheumatology and beyond].
Z Rheumatol. 2021 Sep; 80(7):647-657.ZR

Abstract

Colchicine, the toxin of the autumn crocus, has various anti-inflammatory effects. For this reason, it is being used for the treatment of several autoinflammatory diseases, such as gout or familial Mediterranean fever (FMF). In addition, some interesting studies have been published which suggest the benefits of colchicine in cardiovascular diseases. Furthermore, various anti-inflammatory therapeutic approaches are currently being tested in clinical trials for the treatment of COVID-19. First publications suggest a potential benefit of colchicine in certain disease phases of the virus infection. This article provides an overview of the mechanisms of action, benefits and side effects as well as the various possible uses of colchicine in rheumatology. Furthermore, a brief preview of potential new areas for use of the drug, which are also of interest to rheumatologists, are presented.

Authors+Show Affiliations

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Deutschland.Abteilung für Rheumatologie und Immunologie, Klinikum Bad Bramstedt, Bad Bramstedt, Deutschland.Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Deutschland. martin.krusche@charite.de.

Pub Type(s)

Journal Article

Language

ger

PubMed ID

34097101

Citation

Boyadzhieva, Z, et al. "[Colchicine: Old Medication With New Benefits : Use in Rheumatology and Beyond]." Zeitschrift Fur Rheumatologie, vol. 80, no. 7, 2021, pp. 647-657.
Boyadzhieva Z, Ruffer N, Krusche M. [Colchicine: old medication with new benefits : Use in rheumatology and beyond]. Z Rheumatol. 2021;80(7):647-657.
Boyadzhieva, Z., Ruffer, N., & Krusche, M. (2021). [Colchicine: old medication with new benefits : Use in rheumatology and beyond]. Zeitschrift Fur Rheumatologie, 80(7), 647-657. https://doi.org/10.1007/s00393-021-01017-z
Boyadzhieva Z, Ruffer N, Krusche M. [Colchicine: Old Medication With New Benefits : Use in Rheumatology and Beyond]. Z Rheumatol. 2021;80(7):647-657. PubMed PMID: 34097101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Colchicine: old medication with new benefits : Use in rheumatology and beyond]. AU - Boyadzhieva,Z, AU - Ruffer,N, AU - Krusche,M, Y1 - 2021/06/07/ PY - 2021/04/17/accepted PY - 2021/6/8/pubmed PY - 2021/9/10/medline PY - 2021/6/7/entrez KW - Autoinflammation KW - Autumn crocus KW - COVID-19 KW - Cardiovascular disease KW - Neutrophil granulocytes SP - 647 EP - 657 JF - Zeitschrift fur Rheumatologie JO - Z Rheumatol VL - 80 IS - 7 N2 - Colchicine, the toxin of the autumn crocus, has various anti-inflammatory effects. For this reason, it is being used for the treatment of several autoinflammatory diseases, such as gout or familial Mediterranean fever (FMF). In addition, some interesting studies have been published which suggest the benefits of colchicine in cardiovascular diseases. Furthermore, various anti-inflammatory therapeutic approaches are currently being tested in clinical trials for the treatment of COVID-19. First publications suggest a potential benefit of colchicine in certain disease phases of the virus infection. This article provides an overview of the mechanisms of action, benefits and side effects as well as the various possible uses of colchicine in rheumatology. Furthermore, a brief preview of potential new areas for use of the drug, which are also of interest to rheumatologists, are presented. SN - 1435-1250 UR - https://news.unboundmedicine.com/medline/citation/34097101/[Colchicine:_old_medication_with_new_benefits_:_Use_in_rheumatology_and_beyond]. L2 - https://dx.doi.org/10.1007/s00393-021-01017-z DB - PRIME DP - Unbound Medicine ER -